Previously, Mayon was a program development manager with the AIDS Foundation of Chicago, where she was responsible for nearly $18 million in public and private grants throughout their life cycle. Mayon has also worked in development and evaluation in the social services sector in Los Angeles, where she supported HIV, case management, and mental health services for low-income immigrant communities. Mayon received her master of public health from the University of California, Los Angeles and her bachelor of arts from the University of Chicago.